![]() Overall, these data indicate that colitis can promote a pathological condition of the liver and highlight an important role of Treg in controlling colitis-associated liver inflammation. Finally, we studied immune cell migration using KAEDE mice and found that some of these cells had migrated directly from the inflamed intestine into the liver. Of note, upon depletion of Treg in DEREG mice, DSS colitis promotes accumulation of Th17 cells and a pathological condition of the liver. In contrast, the T cell–mediated colitis model, in which Treg are not abundant, was associated with marked liver inflammation and a pathological condition. In the DSS colitis model, in which Treg were concomitantly increased in the liver, we did not observe an overt pathological condition of the liver. ![]() We observed bacterial translocation and an influx of inflammatory cells, in particular Th17 cells, to the liver during colitis. We analyzed the pathological conditions of the intestine and liver on histological, cellular, and molecular levels. To address this, we used dextran sodium sulfate (DSS) and T cell transfer colitis mouse models. However, whether and how this is linked to the Treg and Th17 cell imbalance is unclear. To explain these associations, one hypothesis is that intestinal inflammation and barrier defects promote liver disease because of the influx of bacteria and inflammatory cells to the liver. Interestingly, it is known that an imbalance between Foxp3 + regulatory T cells (Treg) and Th17 cells is involved in inflammatory bowel disease and also in primary sclerosing cholangitis. WebPath® is a registered service mark and may not be used without permission.Inflammatory bowel disease is associated with extraintestinal diseases such as primary sclerosing cholangitis in the liver. No one may modify, copy, distribute, transmit, display, or publish any materials contained in WebPath® without prior written permission. WebPath® is for your personal and noncommercial use. Comments: If you have comments concerning this Copyright © 1994-2023 by, Savannah, Georgia, USA. As such the information may not be sufficient to address specific patient problems and these should be handled by health care providers familiar with the specific clinical details relevant to the individual. It is not a comprehensive guide to disease. WebPath: A history of 28 years on the internetĭisclaimer: This resource is designed for students and workers in the health care sciences studying pathology. ![]() The 2022 version, 33rd edition, of the Pathology of HIV/AIDS textbook is available These computer-aided instructional materials support educational programs in the health sciences. There are more than 20 tutorials in specific subject areas. For self-assessment and self-directed study there are over 1300 examination items. The WebPath® educational resource contains over 2700 images with text that illustrate gross and microscopic pathologic findings along with radiologic imaging associated with human disease conditions. Laboratory Medicine Curriculum: follow this link for improving knowledge of laboratory medicine principles vital to all practicing physicians.
0 Comments
Leave a Reply. |